Well - tonight was no different. Had to wait for something to download for a client, remoted in tonight, tried to start the install, ran a .exe that auto-extracted itself then auto-ran the setup program. Got an error
Unhandled Exception
Error Number: 0x80004005
Description: Unspecified error Setup will now terminate
Tried various multiple well-known tricks. "Run as Admin", Run in Comparability Mode, Unpacked .exe, then ran the real setup, ran that as admin, ran it from the remote desktop "/console", and searched the internet with no real result.
The solution? InstallShield 2011 has a bug. If you try to run any install that was packed with InstallShield 2011 and the screen has 256 colors or less, the install will fail. Supposedly this has been fixed in InstallShield 2012.
Hopefully this might help someone else out looking for the same error. PS: This was a Sage application.